Abstract Background Predicting and proper ranking of canonical splice sites (SSs) is a challenging problem in bioinformatics and machine learning communities. Any progress in SSs recognition will lead to better understanding of splicing mechanism. We introduce several new approaches of combining a priori knowledge for improved SS detection. https://www.roneverhart.com/Jumbo-New-Spin-Tuz-Karabiber-De-irmeni-14-cm/