Abstract Background Sphingosine-1-phosphate lyase insufficiency syndrome (SPLIS) is a recently recognized inborn error of metabolism associated with steroid-resistant nephrotic syndrome as well as adrenal insufficiency and immunological. neurological. and skin manifestations. SPLIS is caused by inactivating mutations in SGPL1. https://balboasurfandsstylers.shop/product-category/hooded-rashguard/